<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.1d1 20130915//EN" "http://jats.nlm.nih.gov/publishing/1.1d1/JATS-journalpublishing1.dtd">
<article xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" article-type="research-article" xml:lang="en">
<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">SAJPsy</journal-id>
<journal-title-group>
<journal-title>South African Journal of Psychiatry</journal-title>
</journal-title-group>
<issn pub-type="ppub">1608-9685</issn>
<issn pub-type="epub">2078-6786</issn>
<publisher>
<publisher-name>AOSIS</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="publisher-id">SAJPsy-24-1139</article-id>
<article-id pub-id-type="doi">10.4102/sajpsychiatry.v24i0.1139</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Original Research</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Drug use among youth and adults in a population-based survey in South Africa</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes">
<contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-5980-0876</contrib-id>
<name>
<surname>Peltzer</surname>
<given-names>Karl</given-names>
</name>
<xref ref-type="aff" rid="AF0001">1</xref>
<xref ref-type="aff" rid="AF0002">2</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Phaswana-Mafuya</surname>
<given-names>Nancy</given-names>
</name>
<xref ref-type="aff" rid="AF0001">1</xref>
<xref ref-type="aff" rid="AF0003">3</xref>
</contrib>
<aff id="AF0001"><label>1</label>HIV/AIDS/STIs and TB Research Programme, Human Sciences Research Council, South Africa</aff>
<aff id="AF0002"><label>2</label>Department of Research Innovation and Development, University of Limpopo, South Africa</aff>
<aff id="AF0003"><label>3</label>Deputy Vice Chancellor Research and Innovation Office, North West University, South Africa</aff>
</contrib-group>
<author-notes>
<corresp id="cor1"><bold>Corresponding author:</bold> Karl Peltzer, <email xlink:href="kpeltzer@hsrc.ac.za">kpeltzer@hsrc.ac.za</email></corresp>
</author-notes>
<pub-date pub-type="epub"><day>12</day><month>04</month><year>2018</year></pub-date>
<pub-date pub-type="collection"><year>2018</year></pub-date>
<volume>24</volume>
<elocation-id>1139</elocation-id>
<history>
<date date-type="received"><day>05</day><month>06</month><year>2017</year></date>
<date date-type="accepted"><day>12</day><month>09</month><year>2017</year></date>
</history>
<permissions>
<copyright-statement>&#x00A9; 2018. The Authors</copyright-statement>
<copyright-year>2018</copyright-year>
<license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
<license-p>Licensee: AOSIS. This work is licensed under the Creative Commons Attribution License.</license-p>
</license>
</permissions>
<abstract>
<sec id="st1">
<title>Objective</title>
<p>Illicit drug use is a growing public health problem. The aim of the study was to assess the prevalence of drug use and the sociodemographic and health characteristics that influence it among young and adult South Africans.</p>
</sec>
<sec id="st2">
<title>Methods</title>
<p>Data based on the South African national population-based survey in 2012 for 26 453 individuals (52.0&#x0025; women and 48.0&#x0025; men) aged 15 years and older were analysed. Past 3-month drug use was assessed with the &#x2018;Alcohol, Smoking and Substance use Involvement Screening Test (ASSIST)&#x2019;. Bivariate and multivariable logistic regression was conducted to assess the association between sociodemographic factors, health variables and any past 3-month drug use.</p>
</sec>
<sec id="st3">
<title>Results</title>
<p>Overall, any past 3-month drug use was 4.4&#x0025;, 7.9&#x0025; among men and 1.3&#x0025; among women. The proportion of past 3-month cannabis use was 4.0&#x0025;, followed by sedatives or sleeping pills 0.4&#x0025;, amphetamine-type stimulants 0.3&#x0025;, cocaine 0.3&#x0025;, opiates 0.3&#x0025;, inhalants 0.2&#x0025; and hallucinogens 0.1&#x0025;. Among the nine South African provinces, any past 3-month drug use was the highest in the Western Cape (7.1&#x0025;), followed by the Free State (6.3&#x0025;) and Northern Cape (5.2&#x0025;). In adjusted, multivariable, logistic regression analysis among both men and women, younger age, being mixed race and hazardous or harmful alcohol use were associated with any past 3-month drug use. In addition, having been a victim of violent crime and sexual risk behaviour among men and having psychological distress among women were associated with any past 3-month drug use.</p>
</sec>
<sec id="st4">
<title>Conclusion</title>
<p>An increase of any past 3-month drug use from 3.7&#x0025; in 2008 to 4.4&#x0025; in 2012 was observed in South Africa. Prevention and intervention activities targeting drug use, in particular in identified risk groups, need to be strengthened in South Africa.</p>
</sec>
</abstract>
</article-meta>
</front>
<body>
<sec id="s0001">
<title>Introduction</title>
<p>Illicit drug use is a growing public health problem. The estimated global prevalence of illicit drug use (including amphetamines, cannabis, cocaine, opioids, etc.) is 5.3&#x0025; in the past year in 2014.<sup><xref ref-type="bibr" rid="CIT0001">1</xref>,<xref ref-type="bibr" rid="CIT0002">2</xref></sup> The most commonly used illicit drugs globally are cannabis, amphetamine-type stimulants, cocaine and opioids.<sup><xref ref-type="bibr" rid="CIT0002">2</xref></sup> Illicit drug use contributes significantly to the global burden of disease, that is 0.8&#x0025; in 2010.<sup><xref ref-type="bibr" rid="CIT0003">3</xref></sup></p>
<p>In a US population-based survey conducted among individuals aged 12 years and older in 2015, past 1-month (any) illicit drug use was 10.1&#x0025;.<sup><xref ref-type="bibr" rid="CIT0004">4</xref></sup> In a South African population-based national study conducted in 2008, the prevalence of past 3-month (any) drug use was 3.7&#x0025;.<sup><xref ref-type="bibr" rid="CIT0005">5</xref></sup> The highest past 3-month prevalence was for cannabis (3.3&#x0025;), followed by sedatives or sleeping pills (0.8&#x0025;), amphetamine-type stimulants (0.7&#x0025;), cocaine (0.6&#x0025;), opiates (0.5&#x0025;) and hallucinogens (0.5&#x0025;).<sup><xref ref-type="bibr" rid="CIT0005">5</xref></sup></p>
<p>Previous investigations in South Africa and other countries found that specific sociodemographic factors were associated with drug use, including male gender,<sup><xref ref-type="bibr" rid="CIT0005">5</xref>,<xref ref-type="bibr" rid="CIT0006">6</xref></sup> younger age,<sup><xref ref-type="bibr" rid="CIT0005">5</xref></sup> specific population groups (mixed race and white people),<sup><xref ref-type="bibr" rid="CIT0005">5</xref>,<xref ref-type="bibr" rid="CIT0006">6</xref></sup> lower income or not employed<sup><xref ref-type="bibr" rid="CIT0005">5</xref></sup> and geolocality such as urban areas.<sup><xref ref-type="bibr" rid="CIT0005">5</xref>,<xref ref-type="bibr" rid="CIT0007">7</xref></sup> Further, certain health risk behaviours such as common mental disorders (major depression and anxiety disorders),<sup><xref ref-type="bibr" rid="CIT0008">8</xref>,<xref ref-type="bibr" rid="CIT0009">9</xref></sup> alcohol use disorders,<sup><xref ref-type="bibr" rid="CIT0010">10</xref></sup> HIV risk behaviours<sup><xref ref-type="bibr" rid="CIT0011">11</xref></sup> and criminal victimisation<sup><xref ref-type="bibr" rid="CIT0012">12</xref></sup> have been found to be associated with drug use.</p>
<p>In order to update planning on drug use programming, more recent national population-based prevalence data on illicit drug use among adolescents and adults in South Africa are needed. Therefore, the purpose of this secondary analysis was to make more recent estimates on the frequency and type of drug use among women and men 15 years and older available using a nationally representative household survey in 2012.</p>
</sec>
<sec id="s0002">
<title>Method</title>
<sec id="s20003">
<title>Data and sampling</title>
<p>Cross-sectional data from the &#x2018;2012 South African national HIV prevalence, incidence, and behaviour survey&#x2019; was analysed.<sup><xref ref-type="bibr" rid="CIT0013">13</xref></sup> The sampling strategy was stratified by province, type of geolocality and predominant population or racial groups. Using multistage sampling, a random sample of &#x2018;enumeration areas&#x2019; was selected, and within enumeration areas households were randomly selected. All individuals within a household were eligible to participate. Trained and supervised field workers interview-administered a questionnaire. Informed consent was attained prior to the conduct of the interview. The detailed survey methods are described elsewhere.<sup><xref ref-type="bibr" rid="CIT0013">13</xref></sup></p>
<sec id="s30004">
<title>Measures</title>
<p><italic>Drug use</italic> in the past 3 months was assessed with 10 items of the &#x2018;Alcohol, Smoking and Substance Involvement Screening Test (ASSIST)&#x2019;, e.g. &#x2018;In the past 3 months, how often have you used cannabis (dagga, marijuana, pot, grass, hash, etc.)?&#x2019;<sup><xref ref-type="bibr" rid="CIT0014">14</xref></sup> This included the item &#x2018;Besides drugs prescribed by a health professional, have you ever used a drug by injection?&#x2019; The response option was &#x2018;never&#x2019;, &#x2018;Yes. In the past 3 months&#x2019; and &#x2018;Yes, but not in the past 3 months&#x2019;. One item was added &#x2018;Whoonga (mixture of heroin, dagga = cannabis and antiretrovirals)&#x2019;.<sup><xref ref-type="bibr" rid="CIT0013">13</xref></sup> Response options ranged from 1 = never to 5 = almost daily. Any drug use in the past 3 months was coded as 1 and never as 0. All items were added together to indicate the prevalence of any illicit drug use in the past 3 months. Cronbach&#x2019;s alpha for this section of the ASSIST in this sample was 0.61.</p>
<p><bold>Demographic measures</bold> included age, educational level, race (African black people or other races), geolocality, province and employment status.</p>
<p><bold>Psychological distress</bold> was measured with the &#x2018;Kessler Psychological Distress Scale (K-10)&#x2019;.<sup><xref ref-type="bibr" rid="CIT0015">15</xref></sup> The 10-item scale assesses global psychological distress experienced in the past 30 days, e.g. &#x2018;In the past 30 days, how often did you feel so restless that you could not sit still?&#x2019; Response options ranged from 1 = &#x2018;none of the time&#x2019; to 5 = &#x2018;all the time&#x2019;. These scores were added up, with higher total scores indicating higher psychological distress.<sup><xref ref-type="bibr" rid="CIT0015">15</xref></sup> A cut-off of 16 scores and more for detecting depression and anxiety disorders was used, as suggested in a previous validation study of the K-10 in the general population in South Africa.<sup><xref ref-type="bibr" rid="CIT0016">16</xref></sup> Cronbach&#x2019;s alpha for the K-10 in this sample was 0.89.</p>
<p><bold>Hazardous or harmful alcohol use</bold> was assessed with the 10-item &#x2018;Alcohol Disorder Identification Test (AUDIT)&#x2019;, e.g. &#x2018;How often did you have a drink containing alcohol in the past 12 months?&#x2019;<sup><xref ref-type="bibr" rid="CIT0017">17</xref></sup> Response options ranged from 0 to 4, with a summed total range from 0 to 40 scores; a score of 8 or more indicated hazardous or harmful or probable dependent drinking.<sup><xref ref-type="bibr" rid="CIT0017">17</xref></sup> Cronbach&#x2019;s alpha for the AUDIT in this sample was 0.84.</p>
<p><bold>Violent crime victimisation</bold> was assessed with the question, &#x2018;In the past 12 months, have you been a victim of a violent crime where a gun or knife was used to threaten or harm you?&#x2019; Response option was &#x2018;yes&#x2019; or &#x2018;no&#x2019;.<sup><xref ref-type="bibr" rid="CIT0013">13</xref></sup></p>
<p><bold>Sexual risk behaviour</bold> was assessed with two questions. (1) &#x2018;Have you had sex during the past 12 months?&#x2019; (2) &#x2018;Overall, how many sexual partners did you have during the past 12 months?&#x2019; (coded two or more = 1 and 0 to 1 sexual partner = 0).<sup><xref ref-type="bibr" rid="CIT0013">13</xref></sup></p>
</sec>
<sec id="s30005">
<title>Data analysis</title>
<p>Descriptive statistics were used to summarise drug use prevalence, sociodemographic factors and health variables. Associations between the outcome variable of any past 3-month drug use (cannabis, cocaine, amphetamine, inhalants, sedatives, hallucinogens or opiates including <italic>Whoonga</italic>), sociodemographic and health risk-independent variables were examined by calculating odds ratios. Unconditional multivariable logistic regression was utilised to assess the impact of explanatory variables for the outcome of past 3-month drug use prevalence, for women and men separately. All variables that were statistically significant at the <italic>p</italic> &#x003C; 0.05 levels in bivariate analyses were included in the multivariable models. In the article, weighted percentages are presented. The &#x2018;svy&#x2019; command was utilised to take into account the multistage cluster design of the survey. All statistical analyses were performed by using Stata software version 12 (Stata Corp., College Station, TX, USA).</p>
</sec>
</sec>
</sec>
<sec id="s0006">
<title>Ethical consideration</title>
<p>This analysis is based on data on individuals aged 15 years and older who participated in the survey. The study survey proposal was approved by the &#x2018;HSRC Research Ethics Committee (REC: 5/17/11/10)&#x2019; and by the &#x2018;Centers for Disease Control and Prevention&#x2019; (CDC).</p>
</sec>
<sec id="s0007">
<title>Results</title>
<sec id="s20008">
<title>Sample characteristics and prevalence of drug use</title>
<p>Response rates for the interview was 89.5&#x0025;.<sup><xref ref-type="bibr" rid="CIT0013">13</xref></sup> The total sample included 26 453 persons aged 15 years and older, 52.0&#x0025; women and 48.0&#x0025; men. More than half of the participants (52.0&#x0025;) were between 15 and 34 years old, 40.2&#x0025; had Grade 12 or more education, 77.8&#x0025; were from the African black population group, 39.3&#x0025; were formally or informally employed and 51.9&#x0025; lived in urban formal areas. A large proportion of the participants (37.8&#x0025;) reported psychological distress, 11.1&#x0025; hazardous or harmful or probable dependent alcohol use, 14.7&#x0025; had become victim of a violent crime in the past 12 months and 19.1&#x0025; had more than one sexual partner in the past 12 months.</p>
<p>Overall, the past 3-month of any drug use was 4.4&#x0025;, 7.9&#x0025; among men and 1.3&#x0025; among women. The proportion of the past 3-month cannabis use was 4.0&#x0025;, followed by &#x2018;sedatives or sleeping pills (Valium, Mandrax, Serepax, Rohypnol, etc.)&#x2019; 0.4&#x0025;, amphetamine-type stimulants (speed, ecstasy, tik, etc.) 0.3&#x0025;, &#x2018;cocaine (coke, rocks, crack, etc.)&#x2019; 0.3&#x0025;, &#x2018;opiates (heroin, morphine, methadone, codeine, <italic>Whoonga</italic> [mixture of heroin, cannabis and alleged antiretrovirals], etc.)&#x2019; 0.3&#x0025;, &#x2018;inhalants (nitrates, glue, petrol, paint, thinners, etc.)&#x2019; 0.2&#x0025;, and &#x2018;hallucinogens (lysergic acid diethylamide [LSD], acid, mushrooms, Phencyclidine [PCP], Special K, etc.)&#x2019; 0.1&#x0025;. The prevalence of past 3-month drug by injection was 0.6&#x0025;, and the use of <italic>Whoonga</italic> 0.2&#x0025;. Among the nine South African provinces, any past 3-month drug use was the highest in the Western Cape (7.1&#x0025;), followed by the Free State (6.3&#x0025;), Northern Cape (5.2&#x0025;) and Gauteng (4.9&#x0025;) (see <xref ref-type="table" rid="T0001">Table 1</xref>).</p>
<table-wrap id="T0001">
<label>TABLE 1</label>
<caption><p>Past 3-month prevalence of drug use (<italic>N</italic> = 26 453).</p></caption>
<table frame="hsides" rules="groups">
<thead valign="top">
<tr>
<th align="left" rowspan="3" valign="top">Variable</th>
<th align="center" colspan="3">Any drug use</th>
<th align="center">Cannabis</th>
<th align="center">Cocaine</th>
<th align="center">Amphetamine</th>
<th align="center">Inhalants</th>
<th align="center">Sedatives</th>
<th align="center">Hallucinogens</th>
<th align="center">Opiates<xref ref-type="table-fn" rid="TFN0001">&#x2020;</xref></th>
</tr>
<tr>
<th align="center" colspan="10"><hr/></th>
</tr>
<tr>
<th align="center">Total<break/><italic>N</italic> (&#x0025;)</th>
<th align="center">Men<break/>(&#x0025;)</th>
<th align="center">Women<break/>(&#x0025;)</th>
<th align="center">Total<break/>(&#x0025;)</th>
<th align="center">Total<break/>(&#x0025;)</th>
<th align="center">Total<break/>(&#x0025;)</th>
<th align="center">Total<break/>(&#x0025;)</th>
<th align="center">Total<break/>(&#x0025;)</th>
<th align="center">Total<break/>(&#x0025;)</th>
<th align="center">Total<break/>(&#x0025;)</th>
</tr>
</thead>
<tbody valign="top">
<tr>
<td align="left" colspan="11"><bold>Sociodemographics</bold></td>
</tr>
<tr>
<td align="left">All</td>
<td align="center">1092 (4.4)<xref ref-type="table-fn" rid="TFN0002">&#x2021;</xref></td>
<td align="center">7.9</td>
<td align="center">1.3</td>
<td align="center">4.0</td>
<td align="center">0.3</td>
<td align="center">0.3</td>
<td align="center">0.2</td>
<td align="center">0.4</td>
<td align="center">0.1</td>
<td align="center">0.3</td>
</tr>
<tr>
<td align="left" colspan="11"><bold>Age</bold></td>
</tr>
<tr>
<td align="left">&#x2003;15&#x2013;24 (27.6&#x0025;)</td>
<td align="center">422 (5.7)</td>
<td align="center">9.6</td>
<td align="center">1.8</td>
<td align="center">5.6</td>
<td align="center">0.4</td>
<td align="center">0.4</td>
<td align="center">0.2</td>
<td align="center">0.3</td>
<td align="center">0.3</td>
<td align="center">0.4</td>
</tr>
<tr>
<td align="left">&#x2003;25&#x2013;34 (24.4&#x0025;)</td>
<td align="center">316 (6.5)</td>
<td align="center">12.0</td>
<td align="center">1.0</td>
<td align="center">6.1</td>
<td align="center">0.5</td>
<td align="center">0.4</td>
<td align="center">0.3</td>
<td align="center">0.4</td>
<td align="center">0.1</td>
<td align="center">0.5</td>
</tr>
<tr>
<td align="left">&#x2003;35&#x2013;44 (19.1&#x0025;)</td>
<td align="center">168 (3.8)</td>
<td align="center">6.3</td>
<td align="center">1.4</td>
<td align="center">3.2</td>
<td align="center">0.3</td>
<td align="center">0.4</td>
<td align="center">0.2</td>
<td align="center">0.5</td>
<td align="center">0.0</td>
<td align="center">0.2</td>
</tr>
<tr>
<td align="left">&#x2003;45&#x2013;54 (13.1&#x0025;)</td>
<td align="center">93 (2.3)</td>
<td align="center">3.7</td>
<td align="center">1.1</td>
<td align="center">1.8</td>
<td align="center">0.2</td>
<td align="center">0.1</td>
<td align="center">0.0</td>
<td align="center">0.4</td>
<td align="center">0.0</td>
<td align="center">0.1</td>
</tr>
<tr>
<td align="left">&#x2003;55 or more (15.7&#x0025;)</td>
<td align="center">92 (1.5)</td>
<td align="center">2.4</td>
<td align="center">1.0</td>
<td align="center">0.9</td>
<td align="center">0.2</td>
<td align="center">0.1</td>
<td align="center">0.1</td>
<td align="center">0.5</td>
<td align="center">0.0</td>
<td align="center">0.0</td>
</tr>
<tr>
<td align="left"><bold>Education</bold></td>
<td align="left"></td>
<td align="left"></td>
<td align="left"></td>
<td align="left"></td>
<td align="left"></td>
<td align="left"></td>
<td align="left"></td>
<td align="left"></td>
<td align="left"></td>
<td align="left"></td>
</tr>
<tr>
<td align="left">&#x2003;Grade 0&#x2013;7 (18.0&#x0025;)</td>
<td align="center">185 (4.6)</td>
<td align="center">8.4</td>
<td align="center">0.8</td>
<td align="center">4.2</td>
<td align="center">0.4</td>
<td align="center">0.3</td>
<td align="center">0.2</td>
<td align="center">0.5</td>
<td align="center">0.1</td>
<td align="center">0.2</td>
</tr>
<tr>
<td align="left">&#x2003;Grade 8&#x2013;11 (41.8&#x0025;)</td>
<td align="center">451 (4.9)</td>
<td align="center">8.9</td>
<td align="center">1.2</td>
<td align="center">4.5</td>
<td align="center">0.3</td>
<td align="center">0.3</td>
<td align="center">0.2</td>
<td align="center">0.2</td>
<td align="center">0.1</td>
<td align="center">0.4</td>
</tr>
<tr>
<td align="left">&#x2003;Grade 12 or more (40.2&#x0025;)</td>
<td align="center">320 (4.1)</td>
<td align="center">6.7</td>
<td align="center">1.6</td>
<td align="center">3.8</td>
<td align="center">0.3</td>
<td align="center">0.3</td>
<td align="center">0.1</td>
<td align="center">0.6</td>
<td align="center">0.2</td>
<td align="center">0.2</td>
</tr>
<tr>
<td align="left" colspan="11"><bold>Population group</bold></td>
</tr>
<tr>
<td align="left">&#x2003;African black people (77.8&#x0025;)</td>
<td align="center">514 (4.0)</td>
<td align="center">7.5</td>
<td align="center">0.7</td>
<td align="center">3.7</td>
<td align="center">0.2</td>
<td align="center">0.2</td>
<td align="center">0.2</td>
<td align="center">0.2</td>
<td align="center">0.1</td>
<td align="center">0.2</td>
</tr>
<tr>
<td align="left">&#x2003;White people (10.1&#x0025;)</td>
<td align="center">114 (5.0)</td>
<td align="center">6.0</td>
<td align="center">4.0</td>
<td align="center">4.2</td>
<td align="center">0.8</td>
<td align="center">0.6</td>
<td align="center">0.2</td>
<td align="center">1.2</td>
<td align="center">0.1</td>
<td align="center">0.1</td>
</tr>
<tr>
<td align="left">&#x2003;Mixed race (9.3&#x0025;)</td>
<td align="center">361 (8.3)</td>
<td align="center">13.7</td>
<td align="center">3.4</td>
<td align="center">7.4</td>
<td align="center">0.6</td>
<td align="center">1.1</td>
<td align="center">0.4</td>
<td align="center">1.0</td>
<td align="center">0.5</td>
<td align="center">0.9</td>
</tr>
<tr>
<td align="left">&#x2003;Indian or Asian (2.8&#x0025;)</td>
<td align="center">102 (3.2)</td>
<td align="center">4.8</td>
<td align="center">1.7</td>
<td align="center">2.8</td>
<td align="center">0.4</td>
<td align="center">0.3</td>
<td align="center">0.0</td>
<td align="center">1.1</td>
<td align="center">0.2</td>
<td align="center">0.1</td>
</tr>
<tr>
<td align="left" colspan="11"><bold>Employment status</bold></td>
</tr>
<tr>
<td align="left">&#x2003;Employed (39.3&#x0025;)</td>
<td align="center">475 (5.1)</td>
<td align="center">7.4</td>
<td align="center">1.9</td>
<td align="center">4.6</td>
<td align="center">0.3</td>
<td align="center">0.3</td>
<td align="center">0.1</td>
<td align="center">0.5</td>
<td align="center">0.3</td>
<td align="center">0.3</td>
</tr>
<tr>
<td align="left">&#x2003;Unemployed<xref ref-type="table-fn" rid="TFN0003">&#x00B6;</xref> (27.4&#x0025;)</td>
<td align="center">337 (6.1)</td>
<td align="center">12.7</td>
<td align="center">1.1</td>
<td align="center">5.6</td>
<td align="center">0.5</td>
<td align="center">0.4</td>
<td align="center">0.3</td>
<td align="center">0.4</td>
<td align="center">0.0</td>
<td align="center">0.5</td>
</tr>
<tr>
<td align="left">&#x2003;Student (16.8&#x0025;)</td>
<td align="center">132 (3.5)</td>
<td align="center">5.6</td>
<td align="center">1.4</td>
<td align="center">3.4</td>
<td align="center">0.2</td>
<td align="center">0.3</td>
<td align="center">0.2</td>
<td align="center">0.2</td>
<td align="center">0.1</td>
<td align="center">0.2</td>
</tr>
<tr>
<td align="left">&#x2003;Unemployed<xref ref-type="table-fn" rid="TFN0004">&#x00A7;</xref> (13.7&#x0025;)</td>
<td align="center">59 (1.7)</td>
<td align="center">4.9</td>
<td align="center">0.7</td>
<td align="center">1.3</td>
<td align="center">0.3</td>
<td align="center">0.2</td>
<td align="center">0.2</td>
<td align="center">0.3</td>
<td align="center">0.1</td>
<td align="center">0.1</td>
</tr>
<tr>
<td align="left">&#x2003;Unable to work (2.8&#x0025;)</td>
<td align="center">21 (4.4)</td>
<td align="center">7.2</td>
<td align="center">0.2</td>
<td align="center">4.3</td>
<td align="center">0.3</td>
<td align="center">0.0</td>
<td align="center">0.0</td>
<td align="center">0.1</td>
<td align="center">0.0</td>
<td align="center">0.3</td>
</tr>
<tr>
<td align="left" colspan="11"><bold>Residence</bold></td>
</tr>
<tr>
<td align="left">&#x2003;Urban formal (51.9&#x0025;)</td>
<td align="center">743 (5.5)</td>
<td align="center">9.3</td>
<td align="center">2.0</td>
<td align="center">5.0</td>
<td align="center">0.5</td>
<td align="center">0.5</td>
<td align="center">0.2</td>
<td align="center">0.7</td>
<td align="center">0.2</td>
<td align="center">0.4</td>
</tr>
<tr>
<td align="left">&#x2003;Urban informal (7.8&#x0025;)</td>
<td align="center">101 (4.1)</td>
<td align="center">7.7</td>
<td align="center">0.4</td>
<td align="center">3.9</td>
<td align="center">0.1</td>
<td align="center">0.0</td>
<td align="center">0.0</td>
<td align="center">0.2</td>
<td align="center">0.0</td>
<td align="center">0.2</td>
</tr>
<tr>
<td align="left">&#x2003;Rural informal (34.9&#x0025;)</td>
<td align="center">126 (2.8)</td>
<td align="center">5.7</td>
<td align="center">0.4</td>
<td align="center">2.5</td>
<td align="center">0.2</td>
<td align="center">0.1</td>
<td align="center">0.1</td>
<td align="center">0.0</td>
<td align="center">0.0</td>
<td align="center">0.1</td>
</tr>
<tr>
<td align="left">&#x2003;Rural formal (5.4&#x0025;)</td>
<td align="center">122 (5.0)</td>
<td align="center">7.5</td>
<td align="center">1.7</td>
<td align="center">4.9</td>
<td align="center">0.3</td>
<td align="center">0.3</td>
<td align="center">0.2</td>
<td align="center">0.2</td>
<td align="center">0.1</td>
<td align="center">0.5</td>
</tr>
<tr>
<td align="left" colspan="11"><bold>Province</bold></td>
</tr>
<tr>
<td align="left">&#x2003;Western Cape (12.2&#x0025;)</td>
<td align="center">248 (7.1)</td>
<td align="center">11.6</td>
<td align="center">2.9</td>
<td align="center">6.4</td>
<td align="center">0.4</td>
<td align="center">0.8</td>
<td align="center">0.1</td>
<td align="center">0.9</td>
<td align="center">0.1</td>
<td align="center">0.3</td>
</tr>
<tr>
<td align="left">&#x2003;Eastern Cape (11.9&#x0025;)</td>
<td align="center">123 (4.1)</td>
<td align="center">7.3</td>
<td align="center">0.7</td>
<td align="center">3.9</td>
<td align="center">0.2</td>
<td align="center">0.1</td>
<td align="center">0.2</td>
<td align="center">0.3</td>
<td align="center">0.1</td>
<td align="center">0.1</td>
</tr>
<tr>
<td align="left">&#x2003;Northern Cape (2.2&#x0025;)</td>
<td align="center">94 (5.2)</td>
<td align="center">9.3</td>
<td align="center">1.3</td>
<td align="center">4.8</td>
<td align="center">0.2</td>
<td align="center">0.8</td>
<td align="center">0.3</td>
<td align="center">0.4</td>
<td align="center">0.2</td>
<td align="center">0.6</td>
</tr>
<tr>
<td align="left">&#x2003;Free State (5.4&#x0025;)</td>
<td align="center">90 (6.3)</td>
<td align="center">10.3</td>
<td align="center">2.3</td>
<td align="center">5.4</td>
<td align="center">0.4</td>
<td align="center">0.4</td>
<td align="center">0.4</td>
<td align="center">0.9</td>
<td align="center">0.0</td>
<td align="center">0.7</td>
</tr>
<tr>
<td align="left">&#x2003;KwaZulu-Natal (18.5&#x0025;)</td>
<td align="center">209 (3.5)</td>
<td align="center">7.0</td>
<td align="center">0.5</td>
<td align="center">3.4</td>
<td align="center">0.1</td>
<td align="center">0.2</td>
<td align="center">0.0</td>
<td align="center">0.2</td>
<td align="center">0.0</td>
<td align="center">0.1</td>
</tr>
<tr>
<td align="left">&#x2003;Northwest (6.9)</td>
<td align="center">48 (2.7)</td>
<td align="center">5.0</td>
<td align="center">0.4</td>
<td align="center">2.4</td>
<td align="center">0.1</td>
<td align="center">0.1</td>
<td align="center">0.1</td>
<td align="center">0.2</td>
<td align="center">0.1</td>
<td align="center">0.4</td>
</tr>
<tr>
<td align="left">&#x2003;Gauteng (25.5&#x0025;)</td>
<td align="center">175 (4.9)</td>
<td align="center">8.4</td>
<td align="center">1.6</td>
<td align="center">4.6</td>
<td align="center">0.5</td>
<td align="center">0.3</td>
<td align="center">0.2</td>
<td align="center">0.5</td>
<td align="center">0.4</td>
<td align="center">0.4</td>
</tr>
<tr>
<td align="left">&#x2003;Mpumalanga (7.5&#x0025;)</td>
<td align="center">52 (3.6)</td>
<td align="center">5.6</td>
<td align="center">1.4</td>
<td align="center">2.9</td>
<td align="center">0.1</td>
<td align="center">0.3</td>
<td align="center">0.1</td>
<td align="center">0.1</td>
<td align="center">0.0</td>
<td align="center">0.3</td>
</tr>
<tr>
<td align="left">&#x2003;Limpopo (9.9&#x0025;)</td>
<td align="center">53 (2.9)</td>
<td align="center">6.1</td>
<td align="center">0.5</td>
<td align="center">2.2</td>
<td align="center">0.7</td>
<td align="center">0.1</td>
<td align="center">0.3</td>
<td align="center">0.1</td>
<td align="center">0.1</td>
<td align="center">0.1</td>
</tr>
<tr>
<td align="left" colspan="11"><bold>Health risk variables:Psychological distress (</bold>&#x2265;<bold>16)</bold></td>
</tr>
<tr>
<td align="left">&#x2003;No (62.2&#x0025;)</td>
<td align="center">568 (3.8)</td>
<td align="center">6.4</td>
<td align="center">0.9</td>
<td align="center">3.5</td>
<td align="center">0.3</td>
<td align="center">0.2</td>
<td align="center">0.1</td>
<td align="center">0.3</td>
<td align="center">0.1</td>
<td align="center">0.2</td>
</tr>
<tr>
<td align="left">&#x2003;Yes (37.8&#x0025;)</td>
<td align="center">495 (5.4)</td>
<td align="center">10.8</td>
<td align="center">1.7</td>
<td align="center">4.9</td>
<td align="center">0.4</td>
<td align="center">0.5</td>
<td align="center">0.2</td>
<td align="center">0.6</td>
<td align="center">0.2</td>
<td align="center">0.4</td>
</tr>
<tr>
<td align="left" colspan="11"><bold>Hazardous/harmful alcohol use</bold></td>
</tr>
<tr>
<td align="left">&#x2003;No (88.9&#x0025;)</td>
<td align="center">688 (2.9)</td>
<td align="center">5.3</td>
<td align="center">1.1</td>
<td align="center">2.6</td>
<td align="center">0.2</td>
<td align="center">0.2</td>
<td align="center">0.1</td>
<td align="center">0.3</td>
<td align="center">0.1</td>
<td align="center">0.2</td>
</tr>
<tr>
<td align="left">&#x2003;Yes (11.1&#x0025;)</td>
<td align="center">400 (16.4)</td>
<td align="center">18.7</td>
<td align="center">5.5</td>
<td align="center">15.9</td>
<td align="center">1.2</td>
<td align="center">1.4</td>
<td align="center">0.6</td>
<td align="center">0.9</td>
<td align="center">0.3</td>
<td align="center">1.0</td>
</tr>
<tr>
<td align="left" colspan="11"><bold>Victim of violence crime</bold></td>
</tr>
<tr>
<td align="left">&#x2003;No (92.1&#x0025;)</td>
<td align="center">927 (4.0)</td>
<td align="center">7.3</td>
<td align="center">1.1</td>
<td align="center">3.6</td>
<td align="center">0.3</td>
<td align="center">0.2</td>
<td align="center">0.2</td>
<td align="center">0.3</td>
<td align="center">0.1</td>
<td align="center">0.3</td>
</tr>
<tr>
<td align="left">&#x2003;Yes (7.9&#x0025;</td>
<td align="center">159 (9.9)</td>
<td align="center">13.2</td>
<td align="center">4.8</td>
<td align="center">9.4</td>
<td align="center">0.6</td>
<td align="center">1.0</td>
<td align="center">0.4</td>
<td align="center">1.4</td>
<td align="center">0.7</td>
<td align="center">0.4</td>
</tr>
<tr>
<td align="left" colspan="11"><bold>Two or more sexual partners</bold></td>
</tr>
<tr>
<td align="left">&#x2003;No (87.4&#x0025;)</td>
<td align="center">545 (3.7)</td>
<td align="center">6.4</td>
<td align="center">1.3</td>
<td align="center">3.4</td>
<td align="center">0.3</td>
<td align="center">0.2</td>
<td align="center">0.1</td>
<td align="center">0.4</td>
<td align="center">0.1</td>
<td align="center">0.2</td>
</tr>
<tr>
<td align="left">&#x2003;Yes (12.6&#x0025;)</td>
<td align="center">216 (14.6)</td>
<td align="center">16.9</td>
<td align="center">4.2</td>
<td align="center">14.6</td>
<td align="center">1.2</td>
<td align="center">1.2</td>
<td align="center">0.7</td>
<td align="center">0.7</td>
<td align="center">0.8</td>
<td align="center">1.2</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="TFN0001"><label>&#x2020;</label><p>, Includes <italic>Whoonga</italic> = mixture of heroin, cannabis and antiretrovirals;</p></fn>
<fn id="TFN0002"><label>&#x2021;</label><p>, poly drug use (two or more drugs) is 0.5&#x0025;;</p></fn>
<fn id="TFN0003"><label>&#x00B6;</label><p>, not job seeking;</p></fn>
<fn id="TFN0004"><label>&#x00A7;</label><p>, job seeking.</p></fn>
</table-wrap-foot>
</table-wrap>
</sec>
<sec id="s20009">
<title>Associations with any past 3-month drug use</title>
<p>In adjusted, multivariable, logistic regression analysis among men, younger age, being mixed race, not living in a rural informal area, hazardous or harmful alcohol use, having been victim of a violent crime and having two or more sexual partners in the past 12 months were associated with any past 3-month drug use. In adjusted, multivariable, logistic regression analysis among women, younger age, being white people or of mixed race, not unemployed (looking for job), psychological distress and hazardous or harmful alcohol use were associated with any past 3-month drug use (see <xref ref-type="table" rid="T0002">Table 2</xref>).</p>
<table-wrap id="T0002">
<label>TABLE 2</label>
<caption><p>Association between sociodemographics, health variables and drug use.</p></caption>
<table frame="hsides" rules="groups">
<thead valign="top">
<tr>
<th align="left" rowspan="2" valign="top">Sociodemographic variables</th>
<th align="center" colspan="2">Men<hr/></th>
<th align="center" colspan="2">Women<hr/></th>
</tr>
<tr>
<th align="center">Unadjusted odds ratio (95&#x0025; CI)</th>
<th align="center">Adjusted odds ratio (95&#x0025; CI)</th>
<th align="center">Unadjusted odds ratio (95&#x0025; CI)</th>
<th align="center">Adjusted odds ratio (95&#x0025; CI)</th>
</tr>
</thead>
<tbody valign="top">
<tr>
<td align="left" colspan="5"><bold>Age</bold></td>
</tr>
<tr>
<td align="left">&#x2003;15&#x2013;24</td>
<td align="center">1 (Reference)</td>
<td align="center">1 (Reference)</td>
<td align="center">1 (Reference)</td>
<td align="center">1 (Reference)</td>
</tr>
<tr>
<td align="left">&#x2003;25&#x2013;34</td>
<td align="center">1.29 (1.01, 1.65)<xref ref-type="table-fn" rid="TFN0005">&#x002A;</xref></td>
<td align="center">0.78 (0.57, 1.08)</td>
<td align="center">0.53 (0.31, 0.92)<xref ref-type="table-fn" rid="TFN0005">&#x002A;</xref></td>
<td align="center">0.39 (0.20, 0.73)<xref ref-type="table-fn" rid="TFN0006">&#x002A;&#x002A;</xref></td>
</tr>
<tr>
<td align="left">&#x2003;35&#x2013;44</td>
<td align="center">0.63 (0.43, 0.92)<xref ref-type="table-fn" rid="TFN0005">&#x002A;</xref></td>
<td align="center">0.44 (0.28, 0.67)<xref ref-type="table-fn" rid="TFN0007">&#x002A;&#x002A;&#x002A;</xref></td>
<td align="center">0.75 (0.39, 1.43)</td>
<td align="center">0.51 (0.23, 1.12)</td>
</tr>
<tr>
<td align="left">&#x2003;45&#x2013;54</td>
<td align="center">0.37 (0.24, 0.56)<xref ref-type="table-fn" rid="TFN0007">&#x002A;&#x002A;&#x002A;</xref></td>
<td align="center">0.27 (0.16, 0.46)<xref ref-type="table-fn" rid="TFN0007">&#x002A;&#x002A;&#x002A;</xref></td>
<td align="center">0.59 (0.32, 1.08)</td>
<td align="center">0.27 (0.11, 0.63)<xref ref-type="table-fn" rid="TFN0006">&#x002A;&#x002A;</xref></td>
</tr>
<tr>
<td align="left">&#x2003;55 or more</td>
<td align="center">0.23 (0.15, 0.65)<xref ref-type="table-fn" rid="TFN0007">&#x002A;&#x002A;&#x002A;</xref></td>
<td align="center">0.19 (0.10, 0.37)<xref ref-type="table-fn" rid="TFN0007">&#x002A;&#x002A;&#x002A;</xref></td>
<td align="center">0.53 (0.27, 1.03)</td>
<td align="center">0.84 (0.29, 2.40)</td>
</tr>
<tr>
<td align="left" colspan="5"><bold>Education</bold></td>
</tr>
<tr>
<td align="left">&#x2003;Grade 0&#x2013;7</td>
<td align="center">1 (Reference)</td>
<td align="center">-</td>
<td align="center">1 (Reference)</td>
<td align="center">-</td>
</tr>
<tr>
<td align="left">&#x2003;Grade 8&#x2013;11</td>
<td align="center">1.07 (0.78, 1.47)</td>
<td align="center">-</td>
<td align="center">1.39 (0.68, 2.85)</td>
<td align="center">-</td>
</tr>
<tr>
<td align="left">&#x2003;Grade 12 or more</td>
<td align="center">0.79 (0.53, 1.16)</td>
<td align="center">-</td>
<td align="center">1.95 (0.97, 3.92)</td>
<td align="center">-</td>
</tr>
<tr>
<td align="left" colspan="5"><bold>Population group</bold></td>
</tr>
<tr>
<td align="left">&#x2003;African black people</td>
<td align="center">1 (Reference)</td>
<td align="center">1 (Reference)</td>
<td align="center">1 (Reference)</td>
<td align="center">1 (Reference)</td>
</tr>
<tr>
<td align="left">&#x2003;White people</td>
<td align="center">0.78 (0.48, 1.26)</td>
<td align="center">1.12 (0.62, 2.01)</td>
<td align="center">6.23 (3.55, 10.92)<xref ref-type="table-fn" rid="TFN0007">&#x002A;&#x002A;&#x002A;</xref></td>
<td align="center">6.44 (2.93, 14.17)<xref ref-type="table-fn" rid="TFN0007">&#x002A;&#x002A;&#x002A;</xref></td>
</tr>
<tr>
<td align="left">&#x2003;Mixed race</td>
<td align="center">1.95 (1.49, 2.54)<xref ref-type="table-fn" rid="TFN0007">&#x002A;&#x002A;&#x002A;</xref></td>
<td align="center">1.86 (1.30, 2.67)<xref ref-type="table-fn" rid="TFN0007">&#x002A;&#x002A;&#x002A;</xref></td>
<td align="center">5.20 (3.01, 8.98)<xref ref-type="table-fn" rid="TFN0007">&#x002A;&#x002A;&#x002A;</xref></td>
<td align="center">5.18 (2.62, 10.25)<xref ref-type="table-fn" rid="TFN0007">&#x002A;&#x002A;&#x002A;</xref></td>
</tr>
<tr>
<td align="left">&#x2003;Indian or Asian</td>
<td align="center">0.62 (0.42, 0.92)<xref ref-type="table-fn" rid="TFN0005">&#x002A;</xref></td>
<td align="center">0.84 (0.55, 1.35)</td>
<td align="center">2.53 (0.64, 9.99)</td>
<td align="center">4.84 (0.99, 23.53)</td>
</tr>
<tr>
<td align="left" colspan="5"><bold>Employment status</bold></td>
</tr>
<tr>
<td align="left">&#x2003;Employed</td>
<td align="center">1 (Reference)</td>
<td align="center">1 (Reference)</td>
<td align="center">1 (Reference)</td>
<td align="center">1 (Reference)</td>
</tr>
<tr>
<td align="left">&#x2003;Unemployed (not looking)</td>
<td align="center">1.83 (1.41, 2.37)<xref ref-type="table-fn" rid="TFN0007">&#x002A;&#x002A;&#x002A;</xref></td>
<td align="center">1.19 (0.80, 1.76)</td>
<td align="center">0.59 (0.34, 1.02)</td>
<td align="center">0.99 (0.55, 1.81)</td>
</tr>
<tr>
<td align="left">&#x2003;Student</td>
<td align="center">0.75 (0.51, 1.09)</td>
<td align="center">0.70 (0.38, 1.28)</td>
<td align="center">0.72 (0.36, 1.46)</td>
<td align="center">0.73 (0.27, 1.99)</td>
</tr>
<tr>
<td align="left">&#x2003;Unemployed (looking)</td>
<td align="center">0.65 (0.38, 1.10)</td>
<td align="center">1.01 (0.46, 2.22)</td>
<td align="center">0.34 (0.17, 0.67)<xref ref-type="table-fn" rid="TFN0006">&#x002A;&#x002A;</xref></td>
<td align="center">0.31 (0.12, 0.79)<xref ref-type="table-fn" rid="TFN0005">&#x002A;</xref></td>
</tr>
<tr>
<td align="left">&#x2003;Unable to work</td>
<td align="center">0.97 (0.45, 2.09)</td>
<td align="center">0.43 (0.11, 1.74)</td>
<td align="center">0.11 (0.21, 0.58)<xref ref-type="table-fn" rid="TFN0006">&#x002A;&#x002A;</xref></td>
<td align="center">Too few cases</td>
</tr>
<tr>
<td align="left" colspan="5"><bold>Residence</bold></td>
</tr>
<tr>
<td align="left">&#x2003;Urban formal</td>
<td align="center">1 (Reference)</td>
<td align="center">1 (Reference)</td>
<td align="center">1 (Reference)</td>
<td align="center">1 (Reference)</td>
</tr>
<tr>
<td align="left">&#x2003;Urban informal</td>
<td align="center">0.82 (0.57, 1.16)</td>
<td align="center">0.82 (0.53, 1.25)</td>
<td align="center">0.21 (0.07, 0.59)<xref ref-type="table-fn" rid="TFN0006">&#x002A;&#x002A;</xref></td>
<td align="center">0.35 (0.99, 1.25)</td>
</tr>
<tr>
<td align="left">&#x2003;Rural informal</td>
<td align="center">0.59 (0.44, 0.79)<xref ref-type="table-fn" rid="TFN0007">&#x002A;&#x002A;&#x002A;</xref></td>
<td align="center">0.67 (0.45, 0.98)<xref ref-type="table-fn" rid="TFN0005">&#x002A;</xref></td>
<td align="center">0.18 (0.08, 0.41)<xref ref-type="table-fn" rid="TFN0007">&#x002A;&#x002A;&#x002A;</xref></td>
<td align="center">0.39 (0.12, 1.29)</td>
</tr>
<tr>
<td align="left">&#x2003;Rural formal</td>
<td align="center">0.80 (0.47, 1.35)</td>
<td align="center">0.66 (0.35, 1.22)</td>
<td align="center">0.82 (0.41, 1.66)</td>
<td align="center">0.85 (0.32, 2.26)</td>
</tr>
<tr>
<td align="left" colspan="5"><bold>Health variables: Psychological distress (</bold>&#x2265; <bold>16)</bold></td>
</tr>
<tr>
<td align="left">&#x2003;No</td>
<td align="center">1 (Reference)</td>
<td align="center">1 (Reference)</td>
<td align="center">1 (Reference)</td>
<td align="center">1 (Reference)</td>
</tr>
<tr>
<td align="left">&#x2003;Yes</td>
<td align="center">1.77 (1.30, 2.27)<xref ref-type="table-fn" rid="TFN0007">&#x002A;&#x002A;&#x002A;</xref></td>
<td align="center">1.30 (0.96, 1.76)</td>
<td align="center">1.77 (1.15, 2.73)<xref ref-type="table-fn" rid="TFN0006">&#x002A;&#x002A;</xref></td>
<td align="center">2.05 (1.21, 3.47)<xref ref-type="table-fn" rid="TFN0006">&#x002A;&#x002A;</xref></td>
</tr>
<tr>
<td align="left" colspan="5"><bold>Hazardous or harmful alcohol use</bold></td>
</tr>
<tr>
<td align="left">&#x2003;No</td>
<td align="center">1 (Reference)</td>
<td align="center">1 (Reference)</td>
<td align="center">1 (Reference)</td>
<td align="center">1 (Reference)</td>
</tr>
<tr>
<td align="left">&#x2003;Yes</td>
<td align="center">4.10 (3.20, 5.27)<xref ref-type="table-fn" rid="TFN0007">&#x002A;&#x002A;&#x002A;</xref></td>
<td align="center">2.33 (1.73, 3.15)<xref ref-type="table-fn" rid="TFN0007">&#x002A;&#x002A;&#x002A;</xref></td>
<td align="center">5.27 (2.95, 9.44)<xref ref-type="table-fn" rid="TFN0007">&#x002A;&#x002A;&#x002A;</xref></td>
<td align="center">3.14 (1.62, 6.09)<xref ref-type="table-fn" rid="TFN0007">&#x002A;&#x002A;&#x002A;</xref></td>
</tr>
<tr>
<td align="left" colspan="5"><bold>Victim of violence crime</bold></td>
</tr>
<tr>
<td align="left">&#x2003;No</td>
<td align="center">1 (Reference)</td>
<td align="center">1 (Reference)</td>
<td align="center">1 (Reference)</td>
<td align="center">1 (Reference)</td>
</tr>
<tr>
<td align="left">&#x2003;Yes</td>
<td align="center">1.95 (1.36, 2.80)<xref ref-type="table-fn" rid="TFN0006">&#x002A;&#x002A;</xref></td>
<td align="center">1.65 (1.04, 2.61)<xref ref-type="table-fn" rid="TFN0005">&#x002A;</xref></td>
<td align="center">4.77 (1.60, 4.13)<xref ref-type="table-fn" rid="TFN0007">&#x002A;&#x002A;&#x002A;</xref></td>
<td align="center">1.88 (0.97, 3.66)</td>
</tr>
<tr>
<td align="left" colspan="5"><bold>Two or more sexual partners</bold></td>
</tr>
<tr>
<td align="left">&#x2003;No</td>
<td align="center">1 (Reference)</td>
<td align="center">1 (Reference)</td>
<td align="center">1 (Reference)</td>
<td align="center">1 (Reference)</td>
</tr>
<tr>
<td align="left">&#x2003;Yes</td>
<td align="center">2.97 (2.14, 4.12)<xref ref-type="table-fn" rid="TFN0007">&#x002A;&#x002A;&#x002A;</xref></td>
<td align="center">1.78 (1.21, 2.61)<xref ref-type="table-fn" rid="TFN0006">&#x002A;&#x002A;</xref></td>
<td align="center">3.20 (1.57, 6.50)<xref ref-type="table-fn" rid="TFN0007">&#x002A;&#x002A;&#x002A;</xref></td>
<td align="center">1.69 (0.58, 4.87)</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn><p>CI, confidence interval.</p></fn>
<fn id="TFN0005"><label>&#x002A;</label><p><italic>p</italic> &#x003C; 0.05;</p></fn>
<fn id="TFN0006"><label>&#x002A;&#x002A;</label><p><italic>p</italic> &#x003C; 0.01;</p></fn>
<fn id="TFN0007"><label>&#x002A;&#x002A;&#x002A;</label><p><italic>p</italic> &#x003C; 0.001</p></fn>
</table-wrap-foot>
</table-wrap>
</sec>
</sec>
<sec id="s0010">
<title>Discussion</title>
<p>In this very large national population-based study of 2012 among individuals 15 years or older found that any past 3-month drug use was 4.4&#x0025;, which was higher than in the previous 2008 national survey, with 3.7&#x0025;<sup><xref ref-type="bibr" rid="CIT0005">5</xref></sup> but lower than in a survey in the US (past month 10.1&#x0025;).<sup><xref ref-type="bibr" rid="CIT0004">4</xref></sup> Among the different drugs used, the highest past 3-month prevalence was for cannabis (4.0&#x0025;), as found in the 2008 South Africa survey (3.3&#x0025;)<sup><xref ref-type="bibr" rid="CIT0005">5</xref></sup> and also in other countries such as the US.<sup><xref ref-type="bibr" rid="CIT0004">4</xref></sup> Compared to the 2008 South Africa national survey,<sup><xref ref-type="bibr" rid="CIT0005">5</xref></sup> in this 2012 survey the prevalence of past 3-month use increased from 3.3&#x0025; to 4.0&#x0025; for cannabis use, while it decreased for sedatives or sleeping pills from 0.8&#x0025; to 0.4&#x0025;, amphetamine-type stimulants 0.7&#x0025; to 0.3&#x0025;, cocaine 0.6&#x0025; to 0.3&#x0025;, opiates 0.5&#x0025; to 0.3&#x0025;, hallucinogens from 0.5&#x0025; to 0.1&#x0025; and inhalants from 0.5&#x0025; to 0.2&#x0025;.<sup><xref ref-type="bibr" rid="CIT0005">5</xref></sup> The increase in the prevalence of past 3-month drug use from 2008 to 2012 seems to be even higher among the youth (15&#x2013;24 years) from 4.2&#x0025; to 5.7&#x0025;. This seems to show that the increase in any drug use is mainly attributed to an increase in cannabis use and a decrease in poly drug use (two or more drugs) from 0.7&#x0025; in 2008 to 0.5&#x0025; in 2012. The increase in the prevalence of cannabis use may be attributed to lower costs and better accessibility than the other drugs. One review<sup><xref ref-type="bibr" rid="CIT0018">18</xref></sup> indicates a global increase in substance use, including illicit drug use, in particular among young people, emphasising the importance of interventions. The use of <italic>Whoonga</italic> does not seem to be insignificant. In a qualitative study:</p>
<disp-quote>
<p>perceptions of whoonga suggest that it is highly addictive, contains ARVs (notably efavirenz), and poses a threat to the health and safety of those who use it, including increasing the risk of HIV infection.<sup><xref ref-type="bibr" rid="CIT0019">19</xref></sup></p>
</disp-quote>
<p>The use of amphetamine-type stimulants including <italic>tik</italic> and others had been as high as 2.2&#x0025; in the Western Cape province in the 2008 survey,<sup><xref ref-type="bibr" rid="CIT0005">5</xref></sup> but was only 0.8&#x0025; in the Western Cape in this survey, which may indicate some form of control as compared to previously.<sup><xref ref-type="bibr" rid="CIT0020">20</xref></sup> The increase in the use of drugs by injection from 0.3&#x0025; in 2008 to 0.6&#x0025; in 2012 is of concern. A study of 450 people who inject drugs (PWID) in South Africa found that they engaged in high HIV risk behaviour, including 49.0&#x0025; having &#x2018;used contaminated injecting equipment the last time they injected&#x2019;.<sup><xref ref-type="bibr" rid="CIT0021">21</xref></sup></p>
<p>As found in previous studies,<sup><xref ref-type="bibr" rid="CIT0005">5</xref>,<xref ref-type="bibr" rid="CIT0006">6</xref>,<xref ref-type="bibr" rid="CIT0007">7</xref>,<xref ref-type="bibr" rid="CIT0022">22</xref></sup> including in South Africa, the prevalence of drug use was significantly higher among men than women. Further, in agreement with some previous studies,<sup><xref ref-type="bibr" rid="CIT0005">5</xref>,<xref ref-type="bibr" rid="CIT0006">6</xref></sup> this study found that younger age and being from the mixed race population group were associated with drug use. Unemployment was among men in bivariate analysis associated with drug use, as found in some previous studies.<sup><xref ref-type="bibr" rid="CIT0005">5</xref></sup></p>
<p>In agreement with previous reviews,<sup><xref ref-type="bibr" rid="CIT0008">8</xref>,<xref ref-type="bibr" rid="CIT0009">9</xref>,<xref ref-type="bibr" rid="CIT0010">10</xref>,<xref ref-type="bibr" rid="CIT0011">11</xref>,<xref ref-type="bibr" rid="CIT0012">12</xref></sup> this study found that hazardous or harmful or probable dependent alcohol use among both men and women, having had more than one sexual partner in the past 12 months among men, having been victim of violent crime among men and psychological distress (anxiety and depression) among women were associated with drug use. Drug use prevention and intervention have to include co-morbidity factors such as common mental disorders, alcohol use disorders and sexual risk behaviour.</p>
</sec>
<sec id="s0011">
<title>Limitations</title>
<p>This study was cross-sectional and no causative conclusions between independent variables and drug use can be drawn. The data on drug use were collected by self-report and may underreport the true consumption rate.<sup><xref ref-type="bibr" rid="CIT0023">23</xref></sup> Furthermore, the internal consistency of the ASSIST questionnaire for the drug use section was only moderate (0.61). Possible reasons for this may be that alcohol and tobacco use were not assessed as part of the ASSIST and an additional item (<italic>Whoonga</italic> use) had been added. Further, the ASSIST assesses methadone as an opioid, while technically it is a synthetic opioid.</p>
</sec>
<sec id="s0012">
<title>Conclusion</title>
<p>An increase of any illicit drug use prevalence rates was observed from 2008 to 2012 in South Africa. Prevention and intervention activities targeting illicit drug use, in particular in identified risk groups, need to be strengthened in South Africa.</p>
</sec>
</body>
<back>
<ack>
<title>Acknowledgements</title>
<p>The work used data from the Human Sciences Research Council. South African National HIV Prevalence, HIV Incidence, Behaviour and Communication Survey (SABSSM) 2012: Combined &#x2013; All provinces [Data set]. SABSSM 2012 Combined. Version 1.0. Pretoria South Africa: Human Sciences Research Council [producer] 2013, Human Sciences Research Council [distributor] 2016. <ext-link ext-link-type="uri" xlink:href="https://doi.org/doi:10.14749/1485430466">https://doi.org/doi:10.14749/1485430466</ext-link>. The original study was supported by the &#x2018;USA&#x2019;s Centers for Disease Control and Prevention and the Human Sciences Research Council, the Bill &#x0026; Melinda Gates Foundation, the United Nations Children&#x2019;s Fund and the South African National AIDS Council&#x2019;.</p>
<sec id="s20013" sec-type="COI-statement">
<title>Competing interests</title>
<p>The authors declare that they have no financial or personal relationships which may have inappropriately influenced them in writing this article.</p>
</sec>
<sec id="s20014">
<title>Authors&#x2019; contributions</title>
<p>K.P. and N.P.M. designed the study. K.P. analysed the data and wrote the draft article. All authors read and approved the final article.</p>
</sec>
</ack>
<ref-list id="references">
<title>References</title>
<ref id="CIT0001"><label>1.</label><mixed-citation publication-type="book"><person-group person-group-type="author"><collab>United Nations Office on Drugs and Crime</collab></person-group>. <source>World drug report 2016. Sales No. E.16.XI.7</source>. <publisher-loc>New Work</publisher-loc>: <publisher-name>United Nations Publication</publisher-name>; <year>2016</year>.</mixed-citation></ref>
<ref id="CIT0002"><label>2.</label><mixed-citation publication-type="web"><person-group person-group-type="author"><collab>World Health Organization (WHO)</collab></person-group>. <source>Other psychoactive substances [homepage on the Internet]</source>. [cited 2017 Jun 04]. <comment>Available from: <ext-link ext-link-type="uri" xlink:href="http://www.who.int/substance_abuse/facts/psychoactives/en/">http://www.who.int/substance_abuse/facts/psychoactives/en/</ext-link></comment></mixed-citation></ref>
<ref id="CIT0003"><label>3.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Degenhardt</surname> <given-names>L</given-names></string-name>, <string-name><surname>Whiteford</surname> <given-names>HA</given-names></string-name>, <string-name><surname>Ferrari</surname> <given-names>AJ</given-names></string-name>, <etal>et al</etal></person-group>. <article-title>Global burden of disease attributable to illicit drug use and dependence: Findings from the Global Burden of Disease Study 2010</article-title>. <source>Lancet</source>. <year>2013</year>;<volume>382</volume>(<issue>9904</issue>):<fpage>1564</fpage>&#x2013;<lpage>1574</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1016/S0140-6736(13)61530-5">https://doi.org/10.1016/S0140-6736(13)61530-5</ext-link></comment></mixed-citation></ref>
<ref id="CIT0004"><label>4.</label><mixed-citation publication-type="web"><person-group person-group-type="author"><collab>Center for Behavioral Health Statistics and Quality</collab></person-group>. <source>Key substance use and mental health indicators in the United States: Results from the 2015 National Survey on Drug Use and Health [homepage on the Internet]</source>. <comment>HHS Publication No. SMA 16-4984, NSDUH Series H-51</comment>. <year>2016</year> [cited 2017 Jun 04]. <comment>Available from: <ext-link ext-link-type="uri" xlink:href="http://www.samhsa.gov/data/">http://www.samhsa.gov/data/</ext-link></comment></mixed-citation></ref>
<ref id="CIT0005"><label>5.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Peltzer</surname> <given-names>K</given-names></string-name>, <string-name><surname>Ramlagan</surname> <given-names>S</given-names></string-name></person-group>. <article-title>Illicit drug use in South Africa: Findings from a 2008 national population-based survey</article-title>. <source>S Afr J Psychitry</source>. <year>2010</year>;<volume>16</volume>(<issue>1</issue>):<fpage>8</fpage>&#x2013;<lpage>15</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.4102/sajpsychiatry.v16i1.230">https://doi.org/10.4102/sajpsychiatry.v16i1.230</ext-link></comment></mixed-citation></ref>
<ref id="CIT0006"><label>6.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Van Heerden</surname> <given-names>MS</given-names></string-name>, <string-name><surname>Grimsrud</surname> <given-names>AT</given-names></string-name>, <string-name><surname>Seedat</surname> <given-names>S</given-names></string-name>, <string-name><surname>Myer</surname> <given-names>L</given-names></string-name>, <string-name><surname>Williams</surname> <given-names>DR</given-names></string-name>, <string-name><surname>Stein</surname> <given-names>DJ</given-names></string-name></person-group>. <article-title>Patterns of substance use in South Africa: Results from the South African Stress and Health study</article-title>. <source>S Afr Med J</source>. <year>2009</year>;<volume>99</volume>:<fpage>358</fpage>&#x2013;<lpage>366</lpage>.</mixed-citation></ref>
<ref id="CIT0007"><label>7.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Peltzer</surname> <given-names>K</given-names></string-name>, <string-name><surname>Ramlagan</surname> <given-names>S</given-names></string-name>, <string-name><surname>Johnson</surname> <given-names>BD</given-names></string-name>, <string-name><surname>Phaswana-Mafuya</surname> <given-names>N</given-names></string-name></person-group>. <article-title>Illicit drug use and treatment in South Africa: A review</article-title>. <source>Subst Use Misuse</source>. <year>2010</year>;<volume>45</volume>(<issue>13</issue>):<fpage>2221</fpage>&#x2013;<lpage>2243</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3109/10826084.2010.481594">https://doi.org/10.3109/10826084.2010.481594</ext-link></comment></mixed-citation></ref>
<ref id="CIT0008"><label>8.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Conway</surname> <given-names>KP</given-names></string-name>, <string-name><surname>Swendsen</surname> <given-names>J</given-names></string-name>, <string-name><surname>Husky</surname> <given-names>MM</given-names></string-name>, <string-name><surname>He</surname> <given-names>JP</given-names></string-name>, <string-name><surname>Merikangas</surname> <given-names>KR</given-names></string-name></person-group>. <article-title>Association of lifetime mental disorders and subsequent alcohol and illicit drug use: Results from the National Comorbidity Survey-adolescent supplement</article-title>. <source>J Am Acad Child Adolesc Psychiatry</source>. <year>2016</year>;<volume>55</volume>(<issue>4</issue>):<fpage>280</fpage>&#x2013;<lpage>288</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1016/j.jaac.2016.01.006">https://doi.org/10.1016/j.jaac.2016.01.006</ext-link></comment></mixed-citation></ref>
<ref id="CIT0009"><label>9.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Lai</surname> <given-names>HM</given-names></string-name>, <string-name><surname>Cleary</surname> <given-names>M</given-names></string-name>, <string-name><surname>Sitharthan</surname> <given-names>T</given-names></string-name>, <string-name><surname>Hunt</surname> <given-names>GE</given-names></string-name></person-group>. <article-title>Prevalence of comorbid substance use, anxiety and mood disorders in epidemiological surveys, 1990&#x2013;2014: A systematic review and meta-analysis</article-title>. <source>Drug Alcohol Depend</source>. <year>2015</year>;<volume>154</volume>:<fpage>1</fpage>&#x2013;<lpage>13</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1016/j.drugalcdep.2015.05.031">https://doi.org/10.1016/j.drugalcdep.2015.05.031</ext-link></comment></mixed-citation></ref>
<ref id="CIT0010"><label>10.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Teesson</surname> <given-names>M</given-names></string-name>, <string-name><surname>Farrugia</surname> <given-names>P</given-names></string-name>, <string-name><surname>Mills</surname> <given-names>K</given-names></string-name>, <string-name><surname>Hall</surname> <given-names>W</given-names></string-name>, <string-name><surname>Baillie</surname> <given-names>A</given-names></string-name></person-group>. <article-title>Alcohol, tobacco, and prescription drugs: The relationship with illicit drugs in the treatment of substance users</article-title>. <source>Subst Use Misuse</source>. <year>2012</year>;<volume>47</volume>(<issue>8&#x2013;9</issue>):<fpage>963</fpage>&#x2013;<lpage>971</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3109/10826084.2012.663283">https://doi.org/10.3109/10826084.2012.663283</ext-link></comment></mixed-citation></ref>
<ref id="CIT0011"><label>11.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Meader</surname> <given-names>N</given-names></string-name>, <string-name><surname>King</surname> <given-names>K</given-names></string-name>, <string-name><surname>Moe-Byrne</surname> <given-names>T</given-names></string-name>, <etal>et al</etal></person-group>. <article-title>A systematic review on the clustering and co-occurrence of multiple risk behaviours</article-title>. <source>BMC Public Health</source>. <year>2016</year>;<volume>16</volume>:<fpage>657</fpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1186/s12889-016-3373-6">https://doi.org/10.1186/s12889-016-3373-6</ext-link></comment></mixed-citation></ref>
<ref id="CIT0012"><label>12.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Walsh</surname> <given-names>K</given-names></string-name>, <string-name><surname>Resnick</surname> <given-names>HS</given-names></string-name>, <string-name><surname>Danielson</surname> <given-names>CK</given-names></string-name>, <etal>et al</etal></person-group>. <article-title>Patterns of drug and alcohol use associated with lifetime sexual revictimization and current posttraumatic stress disorder among three national samples of adolescent, college, and household-residing women</article-title>. <source>Addict Behav</source>. <year>2014</year>;<volume>39</volume>(<issue>3</issue>):<fpage>684</fpage>&#x2013;<lpage>689</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1016/j.addbeh.2013.12.006">https://doi.org/10.1016/j.addbeh.2013.12.006</ext-link></comment></mixed-citation></ref>
<ref id="CIT0013"><label>13.</label><mixed-citation publication-type="book"><person-group person-group-type="author"><string-name><surname>Shisana</surname> <given-names>O</given-names></string-name>, <string-name><surname>Rehle</surname> <given-names>T</given-names></string-name>, <string-name><surname>Simbayi</surname> <given-names>LC</given-names></string-name>, <etal>et al</etal></person-group>. <source>South African national HIV prevalence, incidence and behaviour survey, 2012</source>. <publisher-loc>Cape Town</publisher-loc>: <publisher-name>HSRC Press</publisher-name>; <year>2014</year>.</mixed-citation></ref>
<ref id="CIT0014"><label>14.</label><mixed-citation publication-type="book"><person-group person-group-type="author"><string-name><surname>Humeniuk</surname> <given-names>RE</given-names></string-name>, <string-name><surname>Henry-Edwards</surname> <given-names>S</given-names></string-name>, <string-name><surname>Ali</surname> <given-names>RL</given-names></string-name>, <string-name><surname>Poznyak</surname> <given-names>V</given-names></string-name>, <string-name><surname>Monteiro</surname> <given-names>M</given-names></string-name></person-group>. <source>The Alcohol, Smoking and Substance Involvement Screening Test (ASSIST): Manual for use in primary care</source>. <publisher-loc>Geneva</publisher-loc>: <publisher-name>World Health Organization</publisher-name>; <year>2010</year>.</mixed-citation></ref>
<ref id="CIT0015"><label>15.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Kessler</surname> <given-names>RC</given-names></string-name>, <string-name><surname>Barker</surname> <given-names>PR</given-names></string-name>, <string-name><surname>Colpe</surname> <given-names>LJ</given-names></string-name>, <etal>et al</etal></person-group>. <article-title>Screening for serious mental illness in the general population</article-title>. <source>Arch Gen Psychiatry</source>. <year>2003</year>;<volume>60</volume>(<issue>2</issue>):<fpage>184e</fpage>&#x2013;<lpage>189e</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1001/archpsyc.60.2.184">https://doi.org/10.1001/archpsyc.60.2.184</ext-link></comment></mixed-citation></ref>
<ref id="CIT0016"><label>16.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Andersen</surname> <given-names>LS</given-names></string-name>, <string-name><surname>Grimsrud</surname> <given-names>A</given-names></string-name>, <string-name><surname>Myer</surname> <given-names>L</given-names></string-name>, <string-name><surname>Williams</surname> <given-names>DR</given-names></string-name>, <string-name><surname>Stein</surname> <given-names>DJ</given-names></string-name>, <string-name><surname>Seedat</surname> <given-names>S</given-names></string-name></person-group>. <article-title>The psychometric properties of the K10 and K6 scales in screening for mood and anxiety disorders in the South African Stress and Health study</article-title>. <source>Int J Methods Psychiatr Res</source>. <year>2011</year>;<volume>20</volume>(<issue>4</issue>):<fpage>215</fpage>&#x2013;<lpage>223</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1002/mpr.351">https://doi.org/10.1002/mpr.351</ext-link></comment></mixed-citation></ref>
<ref id="CIT0017"><label>17.</label><mixed-citation publication-type="book"><person-group person-group-type="author"><string-name><surname>Babor</surname> <given-names>TF</given-names></string-name>, <string-name><surname>Higgins-Biddle</surname> <given-names>JC</given-names></string-name>, <string-name><surname>Saunders</surname> <given-names>JB</given-names></string-name>, <string-name><surname>Monteiro</surname> <given-names>MG</given-names></string-name></person-group>. <chapter-title>AUDIT: The Alcohol Use Disorders Identification Test</chapter-title>. <source>Guidelines for use in primary care</source>. <publisher-loc>Geneva, Switzerland</publisher-loc>: <publisher-name>World Health Organization</publisher-name>; <year>2001</year>.</mixed-citation></ref>
<ref id="CIT0018"><label>18.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Degenhardt</surname> <given-names>L</given-names></string-name>, <string-name><surname>Stockings</surname> <given-names>E</given-names></string-name>, <string-name><surname>Patton</surname> <given-names>G</given-names></string-name>, <string-name><surname>Hall</surname> <given-names>WD</given-names></string-name>, <string-name><surname>Lynskey</surname> <given-names>M</given-names></string-name></person-group>. <article-title>The increasing global health priority of substance use in young people</article-title>. <source>Lancet Psychiatry</source>. <year>2016</year>;<volume>3</volume>(<issue>3</issue>):<fpage>251</fpage>&#x2013;<lpage>264</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1016/S2215-0366(15)00508-8">https://doi.org/10.1016/S2215-0366(15)00508-8</ext-link></comment></mixed-citation></ref>
<ref id="CIT0019"><label>19.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Grelotti</surname> <given-names>DJ</given-names></string-name>, <string-name><surname>Closson</surname> <given-names>EF</given-names></string-name>, <string-name><surname>Smit</surname> <given-names>JA</given-names></string-name>, <etal>et al</etal></person-group>. <article-title>Whoonga: Potential recreational use of HIV antiretroviral medication in South Africa</article-title>. <source>AIDS Behav</source>. <year>2014</year>;<volume>18</volume>(<issue>3</issue>):<fpage>511</fpage>&#x2013;<lpage>518</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1007/s10461-013-0575-0">https://doi.org/10.1007/s10461-013-0575-0</ext-link></comment></mixed-citation></ref>
<ref id="CIT0020"><label>20.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Simbayi</surname> <given-names>LC</given-names></string-name>, <string-name><surname>Kalichman</surname> <given-names>SC</given-names></string-name>, <string-name><surname>Cain</surname> <given-names>D</given-names></string-name>, <string-name><surname>Cherry</surname> <given-names>C</given-names></string-name>, <string-name><surname>Henda</surname> <given-names>N</given-names></string-name>, <string-name><surname>Cloete</surname> <given-names>A</given-names></string-name></person-group>. <article-title>Methamphetamine use and sexual risks for HIV infection in Cape Town, South Africa</article-title>. <source>J Subst Use</source>. <year>2006</year>;<volume>11</volume>(<issue>4</issue>):<fpage>291</fpage>&#x2013;<lpage>300</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1080/14659890600625767">https://doi.org/10.1080/14659890600625767</ext-link></comment></mixed-citation></ref>
<ref id="CIT0021"><label>21.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Scheibe</surname> <given-names>A</given-names></string-name>, <string-name><surname>Makapela</surname> <given-names>D</given-names></string-name>, <string-name><surname>Brown</surname> <given-names>B</given-names></string-name>, <etal>et al</etal></person-group>. <article-title>HIV prevalence and risk among people who inject drugs in five South African cities</article-title>. <source>Int J Drug Policy</source>. <year>2016</year>;<volume>30</volume>:<fpage>107</fpage>&#x2013;<lpage>115</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1016/j.drugpo.2016.01.004">https://doi.org/10.1016/j.drugpo.2016.01.004</ext-link></comment></mixed-citation></ref>
<ref id="CIT0022"><label>22.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Gureje</surname> <given-names>O</given-names></string-name>, <string-name><surname>Degenhardt</surname> <given-names>L</given-names></string-name>, <string-name><surname>Olley</surname> <given-names>B</given-names></string-name>, <etal>et al</etal></person-group>. <article-title>A descriptive epidemiology of substance use and substance use disorders in Nigeria during the early 21st century</article-title>. <source>Drug Alcohol Depend</source>. <year>2007</year>;<volume>91</volume>(<issue>1</issue>):<fpage>1</fpage>&#x2013;<lpage>9</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1016/j.drugalcdep.2007.04.010">https://doi.org/10.1016/j.drugalcdep.2007.04.010</ext-link></comment></mixed-citation></ref>
<ref id="CIT0023"><label>23.</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Gryczynski</surname> <given-names>J</given-names></string-name>, <string-name><surname>Schwartz</surname> <given-names>RP</given-names></string-name>, <string-name><surname>Mitchell</surname> <given-names>SG</given-names></string-name>, <string-name><surname>O&#x2019;Grady</surname> <given-names>KE</given-names></string-name>, <string-name><surname>Ondersma</surname> <given-names>SJ</given-names></string-name></person-group>. <article-title>Hair drug testing and self-reported drug use among primary care patients with moderate-risk illicit drug use</article-title>. <source>Drug Alcohol Depend</source>. <year>2014</year>;<volume>141</volume>:<fpage>44</fpage>&#x2013;<lpage>50</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1016/j.drugalcdep.2014.05.001">https://doi.org/10.1016/j.drugalcdep.2014.05.001</ext-link></comment></mixed-citation></ref>
</ref-list>
<fn-group>
<fn><p><bold>How to cite this article:</bold> Peltzer K, Phaswana-Mafuya N. Drug use among youth and adults in a population-based survey in South Africa. S Afr J Psychiat. 2018;24(0), a1139. <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.4102/sajpsychiatry.v24i0.1139">https://doi.org/10.4102/sajpsychiatry.v24i0.1139</ext-link></p></fn>
</fn-group>
</back>
</article>