Original Research

Velocardiofacial syndrome - a syndrome with many faces

Melinda Lombard, JL Roos
South African Journal of Psychiatry | Vol 17, No 3 | a305 | DOI: https://doi.org/10.4102/sajpsychiatry.v17i3.305 | © 2011 Melinda Lombard, JL Roos | This work is licensed under CC Attribution 4.0
Submitted: 04 May 2011 | Published: 01 September 2011

About the author(s)

Melinda Lombard,, South Africa
JL Roos, Department of Psychiatry, University of Pretoria, and Weskoppies Hospital, Pretoria, South Africa

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Abstract

Velocardiofacial Syndrome (VCFS) can present with many different features. In this paper we review some of these features: working memory deficits, dysmorphic features, co-morbid obsessive compulsive disorder (OCD), early deviant behaviour, functional impairment, and early age of onset of schizophrenia. Some uncommon features found in the five patients studied are discussed. Genetic counselling in these patients and what the future holds in terms of treatment are mentioned. Patients with VCFS can have covert symptoms that can easily be overlooked. For this reason, guidelines to the detection of the abnormalities in these patients are given. The patients whose cases are reviewed are five patients who were diagnosed with VCFS during an ongoing genetic project on the study of schizophrenia in the Afrikaner founder population.

Keywords

VCFS, Pathological laughter, Working memory deficits, Late age of onset

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