Original Research

Antipsychotic medication non-adherence among schizophrenia patients in Central Ethiopia

Minale Tareke, Siranesh Tesfaye, Desalegn Amare, Tilahun Belete, Andargie Abate
South African Journal of Psychiatry | Vol 24 | a1124 | DOI: https://doi.org/10.4102/sajpsychiatry.v24i0.1124 | © 2018 | This work is licensed under CC Attribution 4.0
Submitted: 17 April 2017 | Published: 05 March 2018

About the author(s)

Minale Tareke, College of Medicine and Health Science, Bahir Dar University, Ethiopia
Siranesh Tesfaye, Department of Psychiatry, Felege Hiwot Referral Hospital, Ethiopia
Desalegn Amare, College of Medicine and Health Science, Bahir Dar University, Ethiopia
Tilahun Belete, College of Health Science, Psychiatry Unit, Department of Nursing, Mekelle University, Ethiopia
Andargie Abate, College of Medicine and Health Science, Bahir Dar University, Ethiopia


Background: Despite the fact that adherence to antipsychotic medications is the cornerstone in the treatment and prevention of relapse of the disease, non-adherence is a major problem among schizophrenia patients. The purpose of this study was to assess the magnitude and factors associated with antipsychotic medication non-adherence among schizophrenia patients in Amanuel Mental Specialized Hospital.

Method: An institution-based cross-sectional study was conducted among 412 people with schizophrenia at Amanuel Mental Specialized Hospital from April to May 2014. Non-adherence was assessed using the questionnaire of Morisky medication adherence rating scale and semi-structured questions for assessment of associated factors. Logistic regression analysis was used to assess predictors of non-adherence.

Results: Prevalence of non-adherence was 41.0% among schizophrenia patients. Living in rural areas (adjusted odds ratio [AOR] = 2.07; 95% confidence interval [CI]: 1.31, 3.28), current substance use (AOR = 1.67; 95% CI: 1.09, 2.56), long duration of treatment (AOR = 2.07; 95% CI: 1.22, 3.50) and polypharmacy (AOR = 2.13; 95% CI: 1.34, 3.40) were found to be significantly associated with non-adherence.

Conclusion: The results indicate that non-adherence to antipsychotic medication was a major problem among patients with schizophrenia. Reducing the number of antipsychotic medications and availing drugs in rural areas may decrease the level of non-adherence.


Schizophrenia; Antipsychotics; Non adherence


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Crossref Citations

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