Email this article 
Hide
Show all
Original Research
Antipsychotic medication non-adherence among schizophrenia patients in Central Ethiopia
Submitted: 17 April 2017 | Published: 05 March 2018
About the author(s)
Minale Tareke, College of Medicine and Health Science, Bahir Dar University, EthiopiaSiranesh Tesfaye, Department of Psychiatry, Felege Hiwot Referral Hospital, Ethiopia
Desalegn Amare, College of Medicine and Health Science, Bahir Dar University, Ethiopia
Tilahun Belete, College of Health Science, Psychiatry Unit, Department of Nursing, Mekelle University, Ethiopia
Andargie Abate, College of Medicine and Health Science, Bahir Dar University, Ethiopia
Abstract
Background: Despite the fact that adherence to antipsychotic medications is the cornerstone in the treatment and prevention of relapse of the disease, non-adherence is a major problem among schizophrenia patients. The purpose of this study was to assess the magnitude and factors associated with antipsychotic medication non-adherence among schizophrenia patients in Amanuel Mental Specialized Hospital.
Method: An institution-based cross-sectional study was conducted among 412 people with schizophrenia at Amanuel Mental Specialized Hospital from April to May 2014. Non-adherence was assessed using the questionnaire of Morisky medication adherence rating scale and semi-structured questions for assessment of associated factors. Logistic regression analysis was used to assess predictors of non-adherence.
Results: Prevalence of non-adherence was 41.0% among schizophrenia patients. Living in rural areas (adjusted odds ratio [AOR] = 2.07; 95% confidence interval [CI]: 1.31, 3.28), current substance use (AOR = 1.67; 95% CI: 1.09, 2.56), long duration of treatment (AOR = 2.07; 95% CI: 1.22, 3.50) and polypharmacy (AOR = 2.13; 95% CI: 1.34, 3.40) were found to be significantly associated with non-adherence.
Conclusion: The results indicate that non-adherence to antipsychotic medication was a major problem among patients with schizophrenia. Reducing the number of antipsychotic medications and availing drugs in rural areas may decrease the level of non-adherence.
Keywords
Metrics
Total abstract views: 5190Total article views: 7340
Crossref Citations
1. Predictors of extrapyramidal side effects among patients taking antipsychotic medication at Mekelle psychiatry units, Northern Ethiopia, 2023: unmatched case-control study
Welu Abadi Gebru, Gebregziabher Kidanemariam Asfaw, Kenfe Tesfay Berhe, Tesfaye Derbie Begashaw, Hiwot Gebrewahid Reta, Hagos Tsegabrhan Gebresilassie
BMC Psychiatry vol: 25 issue: 1 year: 2025
doi: 10.1186/s12888-025-07202-7
2. Psychotropic medication non-adherence and its determinants among people living with mental illnesses in Ethiopia: systematic review and meta-analysis study
Gebresilassie Tadesse, Gebremariam Wulie Geremew, Tekletsadik Tekleslassie Alemayehu, Demis Getachew, Digafe Demelash, Setegn Fentahun
BMC Public Health vol: 25 issue: 1 year: 2025
doi: 10.1186/s12889-025-22408-w
3. Experiences of schizophrenia patients with treatment buddy support during the COVID-19 pandemic
Nomhle Mvunelo, Firoza Haffejee, Yasmeen Thandar
Health SA Gesondheid vol: 29 year: 2024
doi: 10.4102/hsag.v29i0.2428
4. The effect of medication adherence on psychosocial adjustment to body weight, image, and self‐esteem in patients with schizophrenia
Sema Nur Türkoğlu Dikmen, Arzu Yüksel, Emel Bahadir‐Yilmaz
Perspectives in Psychiatric Care vol: 58 issue: 4 first page: 2505 year: 2022
doi: 10.1111/ppc.13086
5. Factors influencing the outcome of integrated therapy approach in schizophrenia: A narrative review of the literature
Giulia M. Giordano, Francesco Brando, Pasquale Pezzella, Maria De Angelis, Armida Mucci, Silvana Galderisi
Frontiers in Psychiatry vol: 13 year: 2022
doi: 10.3389/fpsyt.2022.970210
6. Virtual nurse support to enhance antipsychotic adherence in schizophrenia: A South African perspective
Yasmeen Thandar, Nomhle Mvunelo, Deepak Singh, Firoza Haffejee
South African Journal of Psychiatry vol: 31 year: 2025
doi: 10.4102/sajpsychiatry.v31i0.2430
7. Adherence to Typical Antipsychotics among Patients with Schizophrenia in Uganda: A Cross-Sectional Study
Moses Kule, Mark Mohan Kaggwa, Justin Faden
Schizophrenia Research and Treatment vol: 2023 first page: 1 year: 2023
doi: 10.1155/2023/7035893
8. The Influence of Body Image, Insight, and Mental Health Confidence on Medication Adherence in Young Adult Women with Mental Disorders
Eunmi Lee, Mi Heui Jang
International Journal of Environmental Research and Public Health vol: 18 issue: 8 first page: 3866 year: 2021
doi: 10.3390/ijerph18083866
9. Navigating the Challenges: Predictors of Non-Adherence to Psychotropic Medications Among Patients with Severe Mental Illnesses in Ethiopia
Tirsit Ketsela Zeleke, Worku Birhane, Kale Gubae, Bekalu Kebede, Rahel Belete Abebe
Patient Preference and Adherence vol: Volume 17 first page: 2877 year: 2023
doi: 10.2147/PPA.S422659
10. KRONİK RUHSAL BOZUKLUĞU OLAN HASTALARIN TIP DIŞI YARDIM ARAMA DAVRANIŞLARI VE İLAÇ UYUM DÜZEYLERİNİN BELİRLENMESİ
Esma Ceren ŞİŞGİNOĞLU, Nesibe GÜNAY MOLU
SDÜ Tıp Fakültesi Dergisi year: 2024
doi: 10.17343/sdutfd.1184375
11. Antipsychotic medication non-adherence and its associated factors among patients with schizophrenia in Ethiopia: A cross-sectional study
Yuxin Huang, Tafesse Adigawe, Siyuan Tang, Mei Sun
Archives of Psychiatric Nursing vol: 58 first page: 151939 year: 2025
doi: 10.1016/j.apnu.2025.151939
12. Prevalence and Predictors of Nonadherence to Diet and Physical Activity Recommendations among Type 2 Diabetes Patients in Southwest Ethiopia: A Cross-Sectional Study
Getandale Zeleke Negera, Dariowani Charles Epiphanio
International Journal of Endocrinology vol: 2020 first page: 1 year: 2020
doi: 10.1155/2020/1512376
13. Non-adherence level of pharmacotherapy and its predictors among mental disorders in a resource-limited life trajectories: a systematic review and meta-analysis
Woretaw Sisay Zewdu, Samuel Berihun Dagnew, Getachew Yitayew Tarekegn, Taklo Simeneh Yazie, Meswait Asrat Ayicheh, Fisseha Nigussie Dagnew, Tilaye Arega Moges
BMC Psychiatry vol: 25 issue: 1 year: 2025
doi: 10.1186/s12888-025-06838-9
14. The Genetics of Response to and Side Effects of Lithium Treatment in Bipolar Disorder: Future Research Perspectives
Fanny Senner, Mojtaba Oraki Kohshour, Safa Abdalla, Sergi Papiol, Thomas G. Schulze
Frontiers in Pharmacology vol: 12 year: 2021
doi: 10.3389/fphar.2021.638882
15. Non-adherence with the treatment regimen and its associated factors among patients with schizophrenia in Sub-Saharan Africa: a systematic review and meta-analysis
Zenaw Debasu Addisu, Desalegn Getnet Demsie, Chernet Tafere, Ebrahim Abdela Siraj, Taklo Simeneh Yazie, Eyob Getaneh Yimer, Nigus Getaneh Alemu, Yonas Zewdu Milikit, Bamlak Nigussu Wabela, Malede Berihun Yismaw, Melese Alemnew Ayal, Dessale Abate Beyene
Scientific Reports vol: 15 issue: 1 year: 2025
doi: 10.1038/s41598-025-21647-6
16. External Validation of the Population Pharmacokinetic Models of Amisulpride and Remedial Strategies for Delayed or Missed Doses
Desheng Yan, Gehang Ju, Xin Liu, Qing Shao, Yan Zhang, Na Wang, Keyu Yan
Drug Design, Development and Therapy vol: Volume 18 first page: 6345 year: 2024
doi: 10.2147/DDDT.S469149
17. Effectiveness of Group Cognitive Behavioral Therapy in Insight and Treatment Adherence in Schizophrenic Patients: A Randomized Controlled Trial
Samad Fereidooni, Leila Razeghian, Nilofar Fateh
Jundishapur Journal of Chronic Disease Care vol: 12 issue: 3 year: 2023
doi: 10.5812/jjcdc-135541
18. Medication Adherence in a Cross-Diagnostic Sample of Patients From the Affective-to-Psychotic Spectrum: Results From the PsyCourse Study
Sophie-Kathrin Kirchner, Michael Lauseker, Kristina Adorjan, Heike Anderson-Schmidt, Ion-George Anghelescu, Bernhardt T. Baune, Monika Budde, Udo Dannlowski, Detlef E. Dietrich, Andreas J. Fallgatter, Peter Falkai, Christian Figge, Katrin Gade, Urs Heilbronner, Lena Hiendl, Georg Juckel, Janos L. Kalman, Farahnaz Klöhn-Saghatolislam, Carsten Konrad, Fabian U. Lang, Mojtaba Oraki Kohshour, Sergi Papiol, Daniela Reich-Erkelenz, Jens Reimer, Eva Z. Reininghaus, Sabrina K. Schaupp, Max Schmauß, Andrea Schmitt, Eva Christina Schulte, Simon Senner, Carsten Spitzer, Thomas Vogl, Jörg Zimmermann, Alkomiet Hasan, Thomas G. Schulze, Fanny Senner
Frontiers in Psychiatry vol: 12 year: 2022
doi: 10.3389/fpsyt.2021.713060
19. Antipsychotic medication non-adherence and factors associated among patients with schizophrenia in eastern Ethiopia
Fethia Mohammed, Biftu Geda, Tesfaye Assebe Yadeta, Yadeta Dessie
BMC Psychiatry vol: 24 issue: 1 year: 2024
doi: 10.1186/s12888-024-05554-0
20. Medication non-adherence and associated factors among peoples with schizophrenia: multicenter cross-sectional study in Northwest Ethiopia
Fasil Bayafers Tamene, Endalamaw Aschale Mihiretie, Abiy Mulugeta, Abenet Kassaye, Kale Gubae, Samuel Agegnew Wondm
BMC Psychiatry vol: 24 issue: 1 year: 2024
doi: 10.1186/s12888-024-06004-7