Review Article

Early deviant behaviour as a dimension trait and endophenotype in schizophrenia

Johannes L. Roos, Carla Kotzé
South African Journal of Psychiatry | Vol 28 | a1747 | DOI: https://doi.org/10.4102/sajpsychiatry.v28i0.1747 | © 2022 Johannes L. Roos, Carla Kotzé | This work is licensed under CC Attribution 4.0
Submitted: 25 May 2021 | Published: 29 April 2022

About the author(s)

Johannes L. Roos, Department of Psychiatry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa; and, Weskoppies Psychiatric Hospital, Pretoria, South Africa
Carla Kotzé, Department of Psychiatry, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa; and, Weskoppies Psychiatric Hospital, Pretoria, South Africa


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Abstract

Background: In psychiatry, there is still a lack of objective biological diagnostic measurements. It is important to investigate measurements or symptom dimensions that can inform diagnostic assessments and allow for a more personalised approach to patients.

Aim: To discuss how early deviant behaviour (EDB) may be seen as a possible continuous symptom dimension trait and endophenotype in schizophrenia.

Methods: Conducting a commentary review by highlighting some important findings from available literature.

Results: Findings regarding EDB in schizophrenia in a South African genetic sample point towards EDB as a progressive subtype of schizophrenia, with very early onset of illness (even prior to the psychotic symptomatology) and a genetic form of illness.

Conclusion: Valuable information can be gained by enquiring into EDB and viewing it as a continuous symptom dimension trait and endophenotype during the psychiatric diagnostic interview.


Keywords

early onset; deviant behaviour; schizophrenia; endophenotype; continuous symptom dimension

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