Original Research

Magnetic resonance imaging study of corpus callosum abnormalities in patients with different subtypes of schizophrenia

Ebru Unlu, Erman Bagcioglu, Mehtap B Acay, Emre Kacar, Ozan Turamanlar, Yucel Gonul, Mehmet Cevik, Abdullah Akpinar, Kerem Senol Coskun
South African Journal of Psychiatry | Vol 20, No 4 | a574 | DOI: https://doi.org/10.4102/sajpsychiatry.v20i4.574 | © 2014 Ebru Unlu, Erman Bagcioglu, Mehtap B Acay, Emre Kacar, Ozan Turamanlar, Yucel Gonul, Mehmet Cevik, Abdullah Akpinar, Kerem Senol Coskun | This work is licensed under CC Attribution 4.0
Submitted: 25 January 2014 | Published: 30 November 2014

About the author(s)

Ebru Unlu, Department of Radiology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey, Turkey
Erman Bagcioglu, Department of Psychiatry, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey, Turkey
Mehtap B Acay, Department of Radiology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey, Turkey
Emre Kacar, Department of Radiology, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey, Turkey
Ozan Turamanlar, Department of Anatomy, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey, Turkey
Yucel Gonul, Department of Anatomy, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey, Turkey
Mehmet Cevik, Department of Psychiatry, Samsun Mental Health Hospital, Samsun, Turkey, Turkey
Abdullah Akpinar, Department of Psychiatry, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey, Turkey
Kerem Senol Coskun, Department of Psychiatry, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey, Turkey

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Abstract

Background. Reductions in the size of the corpus callosum (CC) have been described for schizophrenia patients, but little is known about the possible regional differences in schizophrenia subtypes (paranoid, disorganised, undifferentiated, residual). 

Methods. We recruited 58 chronically schizophrenic patients with different subtypes, and 31 age-and-gender matched healthy controls. The callosum was extracted from a midsagittal slice from T1 weighted magnetic resonance images, and areas of the total CC, its five subregions, CC length and total brain volume were compared between schizophrenia subtypes and controls. Five subregions were approximately matched to fibre pathways from cortical regions. 

Results. Schizophrenia patients had reduced CC total area and length when compared with controls. Disorganised and undifferentiated schizophrenics had a smaller prefrontal area, while there was no significant difference for the paranoid and residual groups. The premotor/supplementary motor area was smaller in all schizophrenia subtypes. The motor area was smaller only in the disorganised group. A smaller sensory area was found in all subtypes except the residual group. Parietal, temporal and occipital areas were smaller in the paranoid and undifferentiated groups. Total brain volume was smaller in all schizophrenia subtypes compared with controls, but did not reach statistical significance. 

Conclusion. These findings suggest that the heterogeneity of symptoms may lead to the different CC morphological characteristics in schizophrenia subtypes.


Keywords

Schizophrenia subtypes; Morphometric analysis; Corpus callosum subregions; Symptom profiles

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