Original Research

Copeptin levels and blood lipid profile in borderline patients with or without self-mutilation

Sevda Korkmaz, Bilal Üstündağ, Ömer Özer, Gülay Taşçı, Şüheda Kaya, Metin Ateşçelik, Murad Atmaca
South African Journal of Psychiatry | Vol 22, No 1 | a976 | DOI: https://doi.org/10.4102/sajpsychiatry.v22i1.976 | © 2016 Sevda Korkmaz, Bilal Üstündağ, Ömer Özer, Gülay Taşçı, Şüheda Kaya, Metin Ateşçelik, Murad Atmaca | This work is licensed under CC Attribution 4.0
Submitted: 18 February 2016 | Published: 24 October 2016

About the author(s)

Sevda Korkmaz, Department of Psychiatry, Fırat University Medicine Faculty, Turkey
Bilal Üstündağ, Department of Biochemistry, Fırat University Medicine Faculty, Turkey
Ömer Özer, Department of Psychiatry, Fırat University Medicine Faculty, Turkey
Gülay Taşçı, Department of Psychiatry, Fırat University Medicine Faculty, Turkey
Şüheda Kaya, Department of Psychiatry, Fırat University Medicine Faculty, Turkey
Metin Ateşçelik, Department of Emergency, Fırat University Medicine Faculty, Turkey
Murad Atmaca, Department of Psychiatry, Fırat University Medicine Faculty, Turkey


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Abstract

Purpose: Self-mutilation, known as self-harming behaviour of an individual without the intention of suicide, is commonly observed in individuals with borderline personality disorder. The objective of this study is to compare copeptin levels that are known to be related to aggressive behaviour and blood lipid profiles in borderline patients with and without self-mutilation.

Methods: Twenty patients with self-mutilation [SM(+)] and 20 patients without self-mutilation [SM(−)] between the ages of 18 and 49, diagnosed with borderline personality disorder based on DSM-IV-TR(8) diagnostic criteria and attended to by Fırat University Psychiatry Polyclinic, participated in the study. Socio-demographic and clinical data form, Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale (HAMA) and Barrat Impulsivity Scale (BIS) were applied to all participants. Copeptin levels and plasma lipid levels were studied in the blood samples taken from the participants.

Results: Mean copeptin level found in SM(+) group (37.54 ± 18.8 ng/mL) was statistically significantly higher than SM(−) group (18.53 ± 16.6 ng/mL) (p = 0.002). A negative correlation was found between mean copeptin and mean total cholesterol levels (r = −0.436; p = 0.005), and between copeptin and low-density lipoprotein cholesterol (LDL) levels (r = −0.403; p = 0.01) in both SM(+) and SM(−) patient groups. HAMA mean score for SM(+) group was found as 36.45 ± 13.2, and for SM(−) group, it was found as 35.7 ± 12.9. There was a statistically significant difference between the depression points achieved by the two groups (p = 0.046). BIS total points average for SM(+) group was determined as 71 ± 9.71, whereas it was determined as 66.8 ± 7.92 in SM(−) group. There was no statistically significant difference between the groups based on anxiety points. Barrat planning, Barrat motor and Barrat attention points for SM(+) group were higher than the SM(−) group. However, the difference was not statistically significant (p > 0.05).

Conclusion: Findings of the study demonstrated that as cholesterol and LDL levels decreased, copeptin levels increased, and that could be related to the self-mutilation behaviour.


Keywords

Borderline; self-mutilation; copeptin; lipid

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