Case Report

Neuropsychiatric symptoms in a patient with Cushing’s syndrome

Reyna Daya, Faheem Seedat, Emilia Blomerus, Saajidah Bulbulia, Zaheer Bayat
South African Journal of Psychiatry | Vol 28 | a1706 | DOI: https://doi.org/10.4102/sajpsychiatry.v28i0.1706 | © 2022 Reyna Daya, Faheem Seedat, Emilia Blomerus, Saajidah Bulbulia, Zaheer Bayat | This work is licensed under CC Attribution 4.0
Submitted: 05 March 2021 | Published: 18 January 2022

About the author(s)

Reyna Daya, Department of Internal Medicine, Division of Endocrinology, Helen Joseph Hospital, Johannesburg, South Africa; and, Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Faheem Seedat, Department of Internal Medicine, Division of Endocrinology, Helen Joseph Hospital, Johannesburg, South Africa; and, Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Emilia Blomerus, Department of Internal Medicine, Division of Endocrinology, Helen Joseph Hospital, Johannesburg, South Africa
Saajidah Bulbulia, Department of Internal Medicine, Division of Endocrinology, Helen Joseph Hospital, Johannesburg, South Africa; and, Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Zaheer Bayat, Department of Internal Medicine, Division of Endocrinology, Helen Joseph Hospital, Johannesburg, South Africa; and, Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

Abstract

Cushing’s syndrome (CS) may present with different neurological and/or psychiatric symptoms including anxiety, depression, cognitive impairment and psychosis. Psychosis is a rare clinical manifestation, with literature limited to case reports. We report a case of a 52-year-old woman with psychosis secondary to CS who was mis-diagnosed as schizophrenia-like psychosis. This case highlights the importance of considering CS as a differential when ruling out medical causes in patients with either new or persistent mental health disturbances.


Keywords

Cushing’s syndrome; psychosis; neuro-psychiatric disease; depression; cortisol

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